研究人员发现糖尿病性痴呆不同于非糖尿病患者的痴呆症
2010-07-17 19:51:08 来源：丁香园 作者： 评论：0 点击：
Researchers Find Dementia In Diabetics Differs From Dementia In Nondiabetics
研究人员发现糖尿病性痴呆不同于非糖尿病患者的痴呆症
Researchers from Mayo Clinic's Florida campus say that dementia in some diabetics appears to be caused often by vascular disease in the brain, and the dementia that develops in people without diabetes is more likely associated with deposition of the plaque seen in people with Alzheimer's disease.
佛罗 里达州大学的梅奥门诊部的的研究人员报道，在一些糖尿病患者老年痴呆症表现是由大脑中的血管疾病导致的，而没有糖尿病的老年痴呆症，更可能与阿尔茨海默氏 症患者一样，与斑块沉积有关。
The findings will be presented at the Alzheimer's Association International Conference on Alzheimer's Disease 2010 meeting in Honolulu. They resulted from a study conducted among persons with Mexican ancestry but may have relevance to other populations, say the researchers. Also involved in the study were investigators from the University of California, San Francisco.
研究结果将在2010年阿尔茨海默氏症协会在檀香山举办国 际阿尔茨海默氏病大会上报告。 研究人员报道，他们进行的这项研究结果主要来源于是有墨西哥血统的人群，但可能有其他人群的相关。 此外，旧金山的美国加州大学的研究者们也参与了这个项目。
"This helps in understanding diabetes and dementia," says Mayo neurologist Neill Graff-Radford, M.D., who is presenting the findings. "It suggests that the vascular dementia seen in diabetics, which appears to be related to small blood vessel disease and strokes, can potentially be averted if development of diabetes is prevented."
“这有助于了解糖尿病和阿尔茨海默氏症，”医学博士及梅奥神经学家格拉夫•雷德福报告了调查结果： “这表明，在糖尿病患者出现的血管性痴呆，与小血管疾病和中风有关，如果能阻止糖尿病的发展，那么潜在的危险就有可能被避免。
The results agree with a number of autopsy studies conducted on patients with dementia and diabetes, in which vascular abnormalities were found to be related to the dementia but the Alzheimer's pathology of plaque and tangles was not, he says.
其结果与大量进行了尸检的老年痴呆症和糖尿病患者研究一致，糖尿病痴呆症与血管病 变有关而不是与阿尔茨海默氏症的斑块和缠结的病理有关，他说。
The findings also suggest that an experimental blood test to predict development of Alzheimer's disease may be more accurate than some studies of people with dementia have suggested, because those studies included participants with diabetes, says Dr. Graff-Radford. "We now propose that future studies of this test should take into account diabetic status," he says.
该调查结果还表明，血液检测的方 法研究老年痴呆症来预测阿尔茨海默氏病发展可能比想象的更准确一些，因为这些研究中包括了糖尿病患者。格拉夫•拉德福博士在会议上提出。 “我们现在提出，这次测试未来的研究应考虑糖尿病的领域，”他说。
The test is based on discoveries made by Mayo neuroscientists, which measure the ratio of two different kinds of amyloid beta proteins in blood. Plaque found in the brains of Alzheimer's disease patients at autopsy started when the toxic form of amyloid beta, known as Aß42, began to be deposited.
梅奥神经学家制定了检测方案，即 检测血液中两种不同类型的β-淀粉样蛋白的比例。 β-淀粉样蛋白，在开始对阿尔茨海默氏症患者的大脑进行尸检时发现的斑块的组成物质，当时被称为Aß42，因其神经毒性而一直是研究焦点。
Dr. Graff-Radford and his colleagues earlier discovered that if the Aß42 to Aß40 ratio in blood was low, Aß42 was likely being deposited in the brain and that Alzheimer's disease was developing. Five independent studies have confirmed that hypothesis. One found that the risk of Alzheimer's disease was up to 10 times greater in people with a low Aß42/Aß40 ratio. Three additional studies did not find this, and Dr. Graff-Radford suggests those studies may have included enough diabetic patients to skew the results.
格拉夫•拉德福博士和他的同事更早时发现，如果对血液中Aß42 /Aß40比值低，Aß42可能沉积于大脑并加快了阿尔茨海默氏病的发展。 5个独立的研究已经证实这一假设。 一个发现，血液中的Aß42/Aß40比例低，老年痴呆症发病的风险将升高10倍以上。 增设的三个研究点没有发现这一点，格拉夫•拉德福博士认为那些点可能包含太多的糖尿病患者而扭曲了研究结果。
The findings also make sense biologically, Dr. Graff-Radford says. Both the insulin hormone and amyloid beta proteins are degraded by the insulin-degrading enzyme (IDE). He adds that if the blood contains excess insulin, as is the case in diabetics, then IDE preferentially degrades insulin instead of amyloid. "That means there would be higher levels of both Aß42 and Aß40 in the blood of diabetics," he says.
调查结果对于生物学领域也是有有意义的，格拉夫•拉德 福博士说。胰岛素激素和β淀粉样蛋白的都通过胰岛素降解酶（IDE）降解。 他还说，如果血液中含有过多的胰岛素，对于糖尿病患者来说，那么IDE将优先降解胰岛素，而不是β淀粉样蛋白。 “这意味着糖尿病患者的血液中Aß42/Aß40比值将会更高，”他说。
This research comes from a sub-study of an ongoing National Institutes of Health-funded study, the Sacramento Area Latino Study on Aging (SALSA), which includes 1,789 people, primarily Mexican-American. In this study, the researchers analyzed Aß42/Aß40 ratios in 211 participants who developed dementia and 403 "controls" - participants matched in age and gender who remained cognitively normal. Researchers found that among nondiabetics, only the Aß42/Aß40 low ratio was associated with dementia. In diabetics, the ratio of Aß42 to Aß40 was not decreased.
本研究的项目经费来源于国家卫生研究院的健康基金正在进 行的一支分研究，萨克拉门托地区拉美裔老龄研究项目（SALSA），其中包括1,789人，主要是墨西哥裔美国人。 在这项研究中，研究人员对211名患上了老年痴呆症的参与者和年龄性别匹配、认知正常的403名参与者作对照，进行 Aß42/Aß40比率的研究统计。 研究人员发现，在非糖尿病患者中，只有Aß42/Aß40比例低者与老年痴呆症有关。 而糖尿病患者的Aß42 /Aß40比例没有减少。
This study was supported by the National Institutes of Health, the American Health Assistance Foundation, the Robert and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program.
这项研究是在美国国立卫生研究院，美国健康 援助基金会，罗伯特•克拉里•史密斯与阿比盖尔•范•布伦的阿尔茨海默病研究项目的支持下完成。
研究人员发现糖尿病性痴呆不同于非糖尿病患者的痴呆症
Researchers from Mayo Clinic's Florida campus say that dementia in some diabetics appears to be caused often by vascular disease in the brain, and the dementia that develops in people without diabetes is more likely associated with deposition of the plaque seen in people with Alzheimer's disease.
佛罗 里达州大学的梅奥门诊部的的研究人员报道，在一些糖尿病患者老年痴呆症表现是由大脑中的血管疾病导致的，而没有糖尿病的老年痴呆症，更可能与阿尔茨海默氏 症患者一样，与斑块沉积有关。
The findings will be presented at the Alzheimer's Association International Conference on Alzheimer's Disease 2010 meeting in Honolulu. They resulted from a study conducted among persons with Mexican ancestry but may have relevance to other populations, say the researchers. Also involved in the study were investigators from the University of California, San Francisco.
研究结果将在2010年阿尔茨海默氏症协会在檀香山举办国 际阿尔茨海默氏病大会上报告。 研究人员报道，他们进行的这项研究结果主要来源于是有墨西哥血统的人群，但可能有其他人群的相关。 此外，旧金山的美国加州大学的研究者们也参与了这个项目。
"This helps in understanding diabetes and dementia," says Mayo neurologist Neill Graff-Radford, M.D., who is presenting the findings. "It suggests that the vascular dementia seen in diabetics, which appears to be related to small blood vessel disease and strokes, can potentially be averted if development of diabetes is prevented."
“这有助于了解糖尿病和阿尔茨海默氏症，”医学博士及梅奥神经学家格拉夫•雷德福报告了调查结果： “这表明，在糖尿病患者出现的血管性痴呆，与小血管疾病和中风有关，如果能阻止糖尿病的发展，那么潜在的危险就有可能被避免。
The results agree with a number of autopsy studies conducted on patients with dementia and diabetes, in which vascular abnormalities were found to be related to the dementia but the Alzheimer's pathology of plaque and tangles was not, he says.
其结果与大量进行了尸检的老年痴呆症和糖尿病患者研究一致，糖尿病痴呆症与血管病 变有关而不是与阿尔茨海默氏症的斑块和缠结的病理有关，他说。
The findings also suggest that an experimental blood test to predict development of Alzheimer's disease may be more accurate than some studies of people with dementia have suggested, because those studies included participants with diabetes, says Dr. Graff-Radford. "We now propose that future studies of this test should take into account diabetic status," he says.
该调查结果还表明，血液检测的方 法研究老年痴呆症来预测阿尔茨海默氏病发展可能比想象的更准确一些，因为这些研究中包括了糖尿病患者。格拉夫•拉德福博士在会议上提出。 “我们现在提出，这次测试未来的研究应考虑糖尿病的领域，”他说。
The test is based on discoveries made by Mayo neuroscientists, which measure the ratio of two different kinds of amyloid beta proteins in blood. Plaque found in the brains of Alzheimer's disease patients at autopsy started when the toxic form of amyloid beta, known as Aß42, began to be deposited.
梅奥神经学家制定了检测方案，即 检测血液中两种不同类型的β-淀粉样蛋白的比例。 β-淀粉样蛋白，在开始对阿尔茨海默氏症患者的大脑进行尸检时发现的斑块的组成物质，当时被称为Aß42，因其神经毒性而一直是研究焦点。
Dr. Graff-Radford and his colleagues earlier discovered that if the Aß42 to Aß40 ratio in blood was low, Aß42 was likely being deposited in the brain and that Alzheimer's disease was developing. Five independent studies have confirmed that hypothesis. One found that the risk of Alzheimer's disease was up to 10 times greater in people with a low Aß42/Aß40 ratio. Three additional studies did not find this, and Dr. Graff-Radford suggests those studies may have included enough diabetic patients to skew the results.
格拉夫•拉德福博士和他的同事更早时发现，如果对血液中Aß42 /Aß40比值低，Aß42可能沉积于大脑并加快了阿尔茨海默氏病的发展。 5个独立的研究已经证实这一假设。 一个发现，血液中的Aß42/Aß40比例低，老年痴呆症发病的风险将升高10倍以上。 增设的三个研究点没有发现这一点，格拉夫•拉德福博士认为那些点可能包含太多的糖尿病患者而扭曲了研究结果。
The findings also make sense biologically, Dr. Graff-Radford says. Both the insulin hormone and amyloid beta proteins are degraded by the insulin-degrading enzyme (IDE). He adds that if the blood contains excess insulin, as is the case in diabetics, then IDE preferentially degrades insulin instead of amyloid. "That means there would be higher levels of both Aß42 and Aß40 in the blood of diabetics," he says.
调查结果对于生物学领域也是有有意义的，格拉夫•拉德 福博士说。胰岛素激素和β淀粉样蛋白的都通过胰岛素降解酶（IDE）降解。 他还说，如果血液中含有过多的胰岛素，对于糖尿病患者来说，那么IDE将优先降解胰岛素，而不是β淀粉样蛋白。 “这意味着糖尿病患者的血液中Aß42/Aß40比值将会更高，”他说。
This research comes from a sub-study of an ongoing National Institutes of Health-funded study, the Sacramento Area Latino Study on Aging (SALSA), which includes 1,789 people, primarily Mexican-American. In this study, the researchers analyzed Aß42/Aß40 ratios in 211 participants who developed dementia and 403 "controls" - participants matched in age and gender who remained cognitively normal. Researchers found that among nondiabetics, only the Aß42/Aß40 low ratio was associated with dementia. In diabetics, the ratio of Aß42 to Aß40 was not decreased.
本研究的项目经费来源于国家卫生研究院的健康基金正在进 行的一支分研究，萨克拉门托地区拉美裔老龄研究项目（SALSA），其中包括1,789人，主要是墨西哥裔美国人。 在这项研究中，研究人员对211名患上了老年痴呆症的参与者和年龄性别匹配、认知正常的403名参与者作对照，进行 Aß42/Aß40比率的研究统计。 研究人员发现，在非糖尿病患者中，只有Aß42/Aß40比例低者与老年痴呆症有关。 而糖尿病患者的Aß42 /Aß40比例没有减少。
This study was supported by the National Institutes of Health, the American Health Assistance Foundation, the Robert and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program.
这项研究是在美国国立卫生研究院，美国健康 援助基金会，罗伯特•克拉里•史密斯与阿比盖尔•范•布伦的阿尔茨海默病研究项目的支持下完成。
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